WHOLE GENOME SEQUENCING FOR USH2A-ASSOCIATED DISEASE REVEALS SEVERAL PATHOGENIC DEEP-INTRONIC VARIANTS THAT ARE AMENABLE TO SPLICE CORRECTION

Whole genome sequencing for USH2A-associated disease reveals several pathogenic deep-intronic variants that are amenable to splice correction

Summary: A significant number of individuals with a rare disorder such as Usher syndrome (USH) and (non-)syndromic autosomal recessive retinitis pigmentosa (arRP) remain genetically unexplained.Therefore, we assessed subjects suspected of USH2A-associated disease and no or mono-allelic USH2A variants using whole genome sequencing (WGS) followed by

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Assessment of the Quality Indicators of the Carriage Movement by Directly Measuring the Forces of Interaction between the Wheels and Rails

Shampoo This work describes the features and methods of measuring the forces of interaction between the wheel pairs and rails by measuring wheel deformations at control points.The work also contains recommendations for direct measurements of the forces of interaction between the wheels and rails to determine the actual margin of stability of wheel

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Virtual screening of anti-HIV1 compounds against SARS-CoV-2: machine learning modeling, chemoinformatics and molecular dynamics simulation based analysis

Abstract COVID-19 Vests caused by the SARS-CoV-2 is a current global challenge and urgent discovery of potential drugs to combat this pandemic is a need of the hour.3-chymotrypsin-like cysteine protease (3CLpro) enzyme is the vital molecular target against the SARS-CoV-2.Therefore, in the present study, 1528 anti-HIV1compounds were screened by sequ

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